![]() ![]() MB γ neurons prune both their larval axons and dendrites, and then re-grow their axons and dendrites in adult-specific patterns ( Lee et al., 1999), whereas c4da neurons only prune and re-grow their dendrites ( Kuo et al., 2005). These neurons undergo drastic remodeling during metamorphosis. In Drosophila, large-scale axon/dendrite pruning has been well characterized in mushroom body (MB) γ neurons in the brain and class IV dendritic arborization (c4da) sensory neurons in the peripheral nervous system ( Yu and Schuldiner, 2014 Kanamori et al., 2015). Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning. ![]() Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |